James L. Meek
Home phone: (302)-326-1275 james.l.meek@verizon.net
Elected office:
- Nov. 2009 -- Nov. 2021 -- Trustee of New Castle Common
Education:
- 2007 B.A., Computer Science, University of Delaware, Newark, DE
- 1968-1970 Postdoctoral Fellowship (CNS Pharmacology) with Arvid Carlsson (Nobel Prize ’00),
University of Gothenburg, Gothenburg, Sweden
- 1964-1968 Ph.D., Depts. Biochemistry & Psychiatry, University of North Carolina, Chapel Hill, NC.
- 1960-1964 B.S., Chemistry, College of William and Mary, Willliamsburg, VA.
Employment:
- 2012-present: Museum Guide, New Castle Historical Society, Amstel and Dutch houses
- 2007- Dec. 2010: Database and GIS Programmer, Wilmington News Journal
- 2003 -2005 Bioinformatics Analyst, AstraZeneca Co. Enabling Systems Technology Group
- 1990 -2001 Principal Research Scientist, Dupont Merck /Dupont Pharmaceutical Co
- 1984 - 1990 Principal Investigator, Central Research & Development, Dupont Co.
- 1970 - 1984 Pharmacologist, Lab. of Preclinical Pharmacology, NIMH, St. Elizabeths Hospital.
Washington, D.C., laboratory of E. Costa.
Highlights:
- 2016-Present: Started the creation of a public park, the Hermitage Natural Area at 901 Delaware St. in New Castle
- 2015, 2018: Taught three semesters of New Castle History at UD/Osher Life Long Learning
- 2008-Present: Initiated and maintain a web site about New Castle.
Currently it contains >2,000 images, maps and documents according to Google
- 2007-Dec. 2010 Web databases and
interactive online maps at The News Journal for real estate transfers, crime, school test score, shootings, traffic accidents etc. etc.
- 2003-2005 Hierarachical clustering of protein sequences; Implemented open source web Java interfaces for sequence
viewing and protein structure display on company servers.
- 2000 Data Capture: Created Excel->Oracle OO4O interface for direct data entry by biologists.
- 1998 Web creation: Initiated and implemented two working group intranet web sites using Unix servers
and NT desktops. Created Oracle and Access97 databases, web access to compound and protein
structures, and to Powerpoint, Excel and Word documents.
- 1990-2000: Assays: Led routine assays of HIV and HCV enzymes (PR, RT, RDRP).
Pharmacokinetics: Initiated rat dosing, sampling, HPLC measurements, analysis (’90-93’).
High throughput screening: Inositol phosphatase (mania target).
Chemical database: similarity clustering of compound library
- 1984-1990 IP3 ( inositol tris phosphate): Chemical synthesis; HPLC analysis; enzymology
- 1970-1984 Preclinical pharmacology: turnover and assays for acetylcholine, 5HT, GABA
- 1970 CNS amine uptake model used in Prozac discovery lead to first serotonin selective uptake inhibitor used in man
Skills:
- GIS technology: ArcGIS map creation and web display with Java server and Javascript API
- Map--Database integration using MySQL and SQL-Server
- Database development and admin.: MySQL, Oracle, Microsoft SQL Server, Access; web interfacing
- Bioinformatics: Protein sequence analysis; protein structural display
- Computer languages: PHP, Javascript, Java, perl, C++, Visual Basic, FORTRAN, DCL, FORTH, 6502 Assembly language
- Fluent in Swedish.
Societies:
- American Society for Pharmacology and Experimental Therapeutics (1972-2000) , Society for Neuroscience (1978-2000)
Editorial Board:
- Analytical Biochemistry (1975-2003)
Books
-
2020 The History of New Castle, Delaware by Alexander B. Cooper, Esq.
Transcribed and Edited by James Meek
New Castle Historical Society, New Castle, DE
Theater
- 2015, 2016: Dickens' Christmas Carol -- Produced, created script and acted (Ebeneezer Scrooge) in front of the New Castle Courthouse